Thursday, August 31, 2023

A Current Review About Nutrition Interventions for Fibromyalgia




The researcher writes, "This review embraced the literature and showed that the role of dietary supplements on FM remains controversial, although clinical trials with vitamin D, magnesium, iron and probiotics’ supplementation show promising results. In terms of dietary interventions, the administration of olive oil, the replacement diet with ancient cereals, low-calorie diets, vegetarian diets, the low-FODMAPs diet, the gluten-free diet, the monosodium glutamate and aspartame-free diet and the Mediterranean diet all appear to be effective in reducing the symptoms of FM. The majority of the included studies showed a significant improvement in chronic pain, anxiety, depression, cognitive function, sleep pattern and gastrointestinal symptoms. In addition, weight loss seems to be associated with both reduced inflammation and improved quality of life in FM subjects, thus suggesting that body weight could have a functional repercussion in these patients. Therefore, the fact that the improvement has been achieved through different dietary strategies may lead to the hypothesis that both weight loss and the psychosomatic component of the disease could have a major role in the disease." The author goes on to say, " In addition, all of these diets are generally regarded as healthy dietary models, rich in plant foods, antioxidants or fiber, so the fact that people have experienced an improvement in symptoms after almost all dietary interventions suggests that an adequate diet could play a crucial role in the management of FM. However, these results should be interpreted with caution since the aforementioned studies present several biases that limit the robustness of the findings. First of all, most studies have a limited sample size with no possibility of blinding due to the nature of dietary intervention trials. Secondly, outcomes are often analyzed using different methodologies and without considering possible confounding factors. In addition, adherence to the assigned dietary intervention is hardly ever evaluated. Finally, a follow-up is almost never carried out to determine whether the positive effects are maintained over time or are only transient. Therefore, although dietary aspects appear to be a promising complementary approach to treat FM, further research is needed to improve the understanding of the disease and to provide the most effective treatments."

Of course, it is important to talk to your doctor about the supplements you take and any dietary changes you make. The Mediterranean Diet has been shown to increase NRF2 which may reduce the harms from oxidative stress and mast cell generation and activation. Both of which have been implicated in causing some of the symptoms in fibromyalgia. Generally, limiting processed food, limiting saturated fats and increasing fruits and vegetables are good rules to follow when making dietary changes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551285/ Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B. Nutritional Interventions in the Management of Fibromyalgia Syndrome. Nutrients. 2020 Aug 20;12(9):2525. doi: 10.3390/nu12092525. PMID: 32825400; PMCID: PMC7551285.

Wednesday, August 30, 2023

Four Common Childhood Allergic Diseases Have Roots in Dysbiosis




 "The stool samples revealed a bacterial signature that was associated with the children developing any of the four allergies (eczema, asthma, food  and/or hay fever) by five years of age. The bacterial signature is a hallmark of dysbiosis, or an imbalanced gut microbiota, that likely resulted in a compromised intestinal lining and an elevated inflammatory response within the gut."

"Typically, our bodies tolerate the millions of bacteria living in our guts because they do so many good things for our health. Some of the ways we tolerate them are by keeping a strong barrier between them and our immune cells and by limiting inflammatory signals that would call those immune cells into action," says Courtney Hoskinson, a Ph.D. candidate at UBC and first author on the paper. "We found a common breakdown in these mechanisms in babies prior to the development of allergies." Source. MedicalXpress. August 29, 2023. Researchers discover common origin behind major childhood allergies (medicalxpress.com)


More About Allergies in Children

Childhood allergies are a common and serious health problem that affect millions of children around the world. According to the World Health Organization, allergic diseases are among the most prevalent chronic conditions in children, affecting up to 40% of the global population under 18 years of age. Allergies can cause a range of symptoms, from mild to severe, such as sneezing, itching, wheezing, hives, swelling, and anaphylaxis. Allergies can also impair the quality of life of children and their families, affecting their physical, mental, and social well-being. Allergies can be triggered by various factors, such as genetic predisposition, environmental exposure, diet, hygiene, and infections. Some of the most common allergens are pollen, dust mites, animal dander, mold, food, insect stings, and medications. The diagnosis and management of childhood allergies require a multidisciplinary approach that involves medical professionals, parents, teachers, and caregivers. The main goals of treatment are to prevent or reduce exposure to allergens, to control symptoms with medication or immunotherapy, and to educate children and their families about how to cope with allergies and prevent complications.

Monday, August 28, 2023

The Relationship Between Epigenetics, Chronic Fatigue, Fibromyalgia and Other Somatic Illnesses

 


 Hello. From the title of this blog, you might wonder how all these topics are related. Well, it is a stretch but not really a big one. Please bear with me and I think you will see where I am going with this train of thought.

In past posts, I explained how the disruption of the microbiome can lead to the increase or decrease of important brain brain-signaling factors. As we have discussed that with biome disruption, there is an increase in BDNF that may “prime” the gut to become “hypersensitive” which can lead to irritable bowel syndrome (IBS) and other intestinal disease. In addition, dysbiosis causes a decrease in BDNF in certain areas of the brain that may influence cognition and memory. These health conditions can occur much later in life. As we know, IBS is often co-morbid with “somatic” illnesses like fibromyalgia and chronic fatigue syndrome. It has also been demonstrated that stress or trauma can lead to dysbiosis. We also know that dysbiosis results in alterations of communications between the “commensal bacteria” which is bidirectional. Bacteria talk to biological systems and biological systems influence the function of microbiome bacteria. In other words, disruptions in the biome may lead to possible lifelong diseases like CFS and fibromyalgia.

Now, it is important to point out that stress is an environmental factor that can lead to epigenetic changes. In gene expression. Epigenetic changes occur when genes are basically turned “on and off” There are several biological ways this can happen and each one of them is very complex. Notably, these changes occur without changing the genetic code and are “inheritable” in theory. This idea is relatively new, but more and more evidence has demonstrated that these changes can be passed down to subsequent generations. As I mentioned previously, stress and trauma can lead to epigenetic changes in gene expression.

Several studies in the past have suggested that genes may play a role in environmental conditions like fibromyalgia, chronic fatigue syndrome, multiple chemical sensitivities, and PTSD. So far, there is no consensus on which genes may be responsible, but many experts believe, more than likely, it is a variety of them. These changes could account for the different symptoms that are present in different people with any of the four most common of somatic conditions. In support of this theory, a new study has identified potential epigenetic changes in expression on several genes for both fibromyalgia and chronic fatigue syndrome. Basically, this study found "several genes had different methylated sites than normal for fibromyalgia and a few in chronic fatigue syndrome. The results showed that for chronic fatigue syndrome and fibromyalgia, there are alterations in cell signaling and immune functioning. Specifically, for CFS, there is preliminary evidence of epigenetic changes related to hypercortisolism and low-grade inflammation." (1)

Now, I am not saying that epigenetics is the only thing that is at the root of all of these “diseases”. However, I am saying that it is a realistic possibility that environmentally induced changes in gene expression contributes to some of the symptoms. Luckily, epigenetic changes have the potential to be changed by pharmacological and nutritional interventions. Of course, if gene variants are involved, we will have to wait for scientists to find a cure through gene technology.

Source: 1) Fischer S, Kleinstäuber M, Fiori LM, Turecki G, Wagner J, von Känel R. DNA methylation signatures of functional somatic syndromes: Systematic review. Psychosom Med. 2023 Aug 21. doi: 10.1097/PSY.0000000000001237. Epub ahead of print. PMID: 37531610.


A Review on Epigenetics

Sunday, August 27, 2023

Exercise May Improve Abstract Thinking in People with PTSD



In past posts, I have explained how exercise has a positive effect on cognition and memory, especially as we grow older. It also has been proposed that people that have PTSD have "issues" with executive function in making decisions. Specifically, the ability to make abstract decisions based on their choices is impaired. A new study has shown that moderate aerobic exercise can influence the ability to make more complex decisions in women with PTSD. This is true and even more so when a person engages in moderate verses light-intensity exercise. Also, the positive effects of exercise were seen whether a task was given right after finishing the exercise or when a task was given after a longer delay. These results show there is a positive effect of exercise in people with PTSD when making more complex decisions. Study participants were all women, but I would assume these positive effects would also occur in men. 

Source: The Influence of Aerobic Exercise on Model-based Decision Making in Women with Posttraumatic Stress Disorder, Kevin M Comie, Ameera Azar...Josh M. Cisler. Journal of Mood Anxiety Disorders. August 2, 2023. Published online July 27, 2023. 


More About Executive Function and PTSD

Executive function and PTSD are two concepts that are often related in psychological research. Executive function refers to the cognitive processes that enable us to plan, organize, monitor, and control our actions and thoughts. PTSD, or post-traumatic stress disorder, is a mental health condition that can develop after experiencing or witnessing a traumatic event, such as war, violence, or abuse. PTSD can impair executive function by causing difficulties with attention, memory, decision-making, and emotional regulation. This can affect various aspects of life, such as work, education, and relationships. Therefore, it is important to assess and treat executive function problems in people with PTSD, using evidence-based interventions such as cognitive-behavioral therapy, mindfulness, or neurofeedback.


Age-Related Hearing Loss May Be Reversible.


According to scientists a decrease in cholesterol in the ear is responsible for age-related hearing loss. Also, by replacing the loss of cholesterol with a phytosterol supplement prevented the loss of hearing in a mouse model. Cholesterol is involved in the stretch response of sensory cells in reaction to sound and it decreases with age leading to hearing loss. In a new study, researchers found that an enzyme, CYP46A1, was overexpressed in aged mice resulting in less cholesterol. This enzyme is responsible for breaking down cholesterol. In a young mice model, scientists showed improved function of sensory cells when given phytosterols in addition to a CYP46A1-activating drug. The results of the study "demonstrated that 1) aging triggers cholesterol loss 2) a common drug reproduced the cholesterol loss and 3) phytosterols partly reversed the defects in sensory function." This is the first study that demonstrated that reversing hearing loss is possible with a common supplement, although more studies need to be done. Source: Study Shows that Common Supplement May Reduce Natural Hearing Loss. Medical Xpress. Friday, August 25, 2023. 


What is a phytosterol?

Phytosterols are natural compounds found in plants that have a similar structure to cholesterol. They are also known as plant sterols or stanols. Phytosterols are important for the health of plant cells, but they can also benefit human health by lowering cholesterol levels and reducing the risk of heart disease.


How do phytosterols work?

Phytosterols work by blocking the absorption of cholesterol in the small intestine. When you eat foods that contain cholesterol, such as eggs, meat, or dairy products, some of it is absorbed into your bloodstream and contributes to your total cholesterol level. However, when you eat foods that contain phytosterols, such as nuts, seeds, vegetable oils, or margarine, they compete with cholesterol for absorption and prevent some of it from entering your bloodstream. This lowers your LDL (bad) cholesterol level and improves your cholesterol ratio.


How much phytosterols do you need?

The recommended intake of phytosterols for lowering cholesterol is at least 2 grams per day. This can be achieved by eating foods that naturally contain phytosterols, such as fruits, vegetables, legumes, grains, nuts, and seeds. However, these foods only provide small amounts of phytosterols, ranging from 0.1 to 0.3 grams per 100 grams of food. Therefore, you may need to consume foods that are fortified with phytosterols, such as margarine, yogurt, milk, bread, or cereal. These products can provide up to 0.8 grams of phytosterols per serving. You can also take supplements that contain phytosterols in capsule or tablet form.


What are the benefits and downsides of phytosterols?

Phytosterols have been shown to lower LDL (bad) cholesterol levels by 5% to 15% in people with high cholesterol. This can reduce the risk of heart attack and stroke by 10% to 20%. Phytosterols may also have anti-inflammatory, anti-cancer, and anti-diabetic effects, but more research is needed to confirm these benefits.

Phytosterols are generally safe and well-tolerated by most people. However, some people may experience side effects such as nausea, diarrhea, gas, or bloating. Phytosterols may also interfere with the absorption of some fat-soluble vitamins, such as vitamin A, D, E, and K. Therefore, you should consult your doctor before taking phytosterols if you have any medical conditions or take any medications that affect your vitamin levels.


Summary

Phytosterols are plant compounds that can help lower your cholesterol levels and protect your heart health. You can get them from natural foods or fortified products or supplements. However, you should be aware of the possible side effects and interactions with vitamins and medications.

Saturday, August 26, 2023

Living with Environmental Illness. This is My Story!

I do not usually talk about myself much on this blog because I am not sure anyone really wants to hear my story, but I am going to do it today. 

I think I always have had MCS/MCAS because there were times in my life when I would react to something and never could identify what that was. I know one time it was a bonfire. I went to bed with a spot on my face and several hours later I had splotches all over my body. I had headaches for a while in college. The kind where you just lay there with the lights off and hope you make it to the next day. I ended up in the hospital for vertigo one time and I believe that was after my apartment managers sprayed my place for bugs. 

Two other times, I ended up in the hospital for PTSD and along with it I had severe leg spasms, a fever and itching. No one was concerned about the itching, but I found even wearing my clothes was uncomfortable. Both times when I went to the hospital, I lost some of my long-term and short-term memory. I know that is from the PTSD but just wonder if some of that was from neuroinflammation. It does eventually come back but it takes a while. 

I was first diagnosed with chronic fatigue syndrome in 1983 when I was a freshman in college. I can remember I got a bad case of pneumonia probably because my roommate from "He$$" smoked like a smokestack. There was no escape from it. After my bout with pneumonia, it took months to recover to a point where I could function and live a regular life. I had bouts of CFS every time I was exposed to someone that was sick. I could almost bet on it. It made college life hard, and it took me twice as long to finally finish my education.

Since 1983 I have been in and out of remission with chronic fatigue syndrome from different stressors. I know what I must do to stay healthy but sometimes life gets in the way. There is no way to avoid every stressor a person will encounter. You can't live life that way. In 2006, I was put in a dangerous situation that triggered my PTSD and MCS and finally found a doctor who would help. This doctor had worked for the military and worked with Gulf War Syndrome patients. I was lucky to have found him because he was only the second doctor, I ever had that really understood CFS and MCS. I appreciated his advice and his skill. Interestingly, he had a strong belief that nutrition could heal. He put me on some kind of food smoothie stuff for a while. It is a prescription and I have not ever seen it since. At that point in time, they really did not understand how polyphenols act on the body and their mode of action. Today, we understand a lot more about how nutrition really can heal. 

My education is in biology and health education. After I met Dr. Anderson, I took it upon myself to learn from a scientific perspective about these diseases. Yes, they are diseases and I have genes that do not work right. It may be a variant or an epigenetic change because I also believe my mother had it too. I watched her suffer for years with weird ailments and mental health issues. I have always felt that they were connected. I learned several years ago about NRF2 and its impact on the antioxidant system and neurology. One thing I have not mentioned is that I have neuropathy and the doctor I mentioned above put me on B12 shots for my legs. (At this point, neuropathy was not in the case definition of CFS) It was when I made the connection between NRF2 and neurology that I started to learn about the biological pathway it regulates in earnest. Now, every researcher knows about NRF2, but I think I must have been one of the first that realized that the foods that activate it might help my CFS and MCAS/MCS. I never did read the label of the food that doctor gave me, but I would guess it had a lot of NRF2 activators in it. It tasted really good, so I never questioned what was in it. 

Today, I am out of remission for both my MCS and my chronic fatigue syndrome. The stress from when my house was flooded from hurricane Ian and being relocated for several months finally took its toll. I am also back to learning more about these diseases and brush-up on the science that I forgot. I am back to my diet again and it is helping but repairing your gut and psyche takes a while. I consider myself lucky that I only had mold growth on the cabinets which were remediated because it could have been a lot worse. Now, I need to get over the PTSD from Ian because I was trapped in the house for over two days after it flooded. Oh yes, with all my research, all these conditions are closely related and now experts are starting to believe it too!

Small Fiber Neuropathy is not Always Discussed in CFS/ME and Fibromyalgia


Neuropathic pain is a type of pain that results from damage to the nervous system and is not discussed a lot. It is often "described as a burning, tingling, or shooting sensation. Chronic fatigue syndrome (CFS) and fibromyalgia are two conditions that have been linked to neuropathic pain  (1-3) In fact, research suggests that many people with CFS and fibromyalgia have something called small fiber neuropathy, which is a type of nerve damage that affects the small nerve fibers near the surface of the skin and deals with pain and temperature sensation. (1) Symptoms of small fiber neuropathy include sharp, shooting pains, orthostatic hypotension (dizziness upon standing), autonomic symptoms, skin changes related to the interrupted nerve supply, incontinence, sexual dysfunction, and other neuropathic symptoms.(1) Skin biopsies can be used to check for small fiber neuropathy in patients who have these symptoms. However, some doctors say that skin biopsies aren’t reliable enough alone and should only be used to confirm a diagnosis based on examination and history. (1)

Small Fiber Neuropathy in Fibromyalgia and CFS. By Adrienne Dellwo Update May 22, 2022. Small Fiber Neuropathy in Fibromyalgia and CFS (verywellhealth.com)

Paresthesia in Fibromyalgia and Chronic Fatigue Syndrome. By Adrienne Dellwo .Updated on April 09, 2023. 

Why Fibromyalgia Is Neuropathic: Central sensitization is one explanation.  Cleveland Clinic.

Symptoms of ME/CFS. CDC. 

Don't Put Bananas in Your Smoothie to Get Full Benefit from Berries

 


According to a new study by the University of California-Davis, "you should no longer put bananas in your morning smoothies to get the full benefit of the flavanols from the fruits you added. The researchers found that an enzyme called polyphenol oxidase (PPO) in certain fruits like bananas may prevent the digestive absorption of the flavanols from berries." They further said, "that the participants of the study had an 84% lower level of flavanols after drinking a smoothie of berries and bananas then controls who drink a smoothie without bananas. This just goes to show how a simple food preparation can affect the nutritional value of it." (1)

Note: You can still eat bananas just not with your berries.

What are flavanols?

Flavanols are a type of natural compounds called flavonoids that are found in various fruits, vegetables, and plants. Flavanols have a 3-hydroxyflavone backbone and differ from other flavonoids in their chemical structure. Flavanols are also known as flavan-3-ols or catechins.

Flavanols have many potential health benefits, such as:

- Acting as antioxidants that can neutralize harmful free radicals and reduce oxidative stress 

- Having anti-inflammatory, anticarcinogenic, antiviral, and antimicrobial properties

- Lowering the risk of cardiovascular disease, diabetes, and some types of cancer 

Some of the foods and drinks that are rich in flavanols are:

- Cocoa and chocolate 

- Tea (especially green and black tea) 

- Grapes and red wine 

- Berries (such as cranberries, raspberries, strawberries, and blueberries) 

- Apples and pears 

Flavanols are a beneficial part of a balanced diet that includes plenty of fruits and vegetables. They can help protect your health and prevent chronic diseases.

Source: New Research Reveals Why You Shouldn't Add a Banana to Your Smoothies. University of California - Davis. ScitechDaily.com. August 25, 2023. New Research Reveals Why You Shouldn’t Add a Banana to Your Smoothies (scitechdaily.com)


Friday, August 25, 2023

Mast Cell Activation Involved in Immune Reaction to Mold



Molds are " all species of small fungi whose spores can be pathogenic to humans and produce an inflammatory response that causes disease. Opportunistic common pathogenic fungus can cause mycoses in immunocompromised patients and cause allergic lung illness and worsen asthma inflammation. Spores may pass through the pulmonary airways and be recognized by innate immune cells like mast cells (MCs) via TLR signaling. Histamine, proteases (tryptase, chimase), pro-inflammatory cytokines/chemokines, and arachidonic acid are produced by activated MCs. MCs activated by fungus raise PGD2 levels and cause hypersensitivity disorders with symptoms such respiratory tract and eye irritation, recurrent sinusitis, bronchitis, cough, fatigue, nausea, headaches, and brain fog. Thus, fungi activate the innate immune response through TLRs, releasing myeloid differentiation factor 88 (MyD88), which causes cascade events to stimulate AP-1, NF-kB, and inflammatory IL-1 family members. Fungal activation of MCs to release pro-inflammatory cytokines may be blocked by IL-37, a novel anti-inflammatory IL-1 family member." 

Kritas SK, Gallenga CE, D Ovidio C, Ronconi G, Caraffa Al, Toniato E, Lauritano D, Conti P. Impact of mold on mast cell-cytokine immune response. J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4):763-768. PMID: 30043558.

How Bacteria May Contribute to Neuroinflammation and Environmental Illness


We have included studies specifically investigating platelets and TRP metabolism in relation to inflammation, neuroinflammation and neuropsychiatric disorders. Alteration in microbial composition due to stress could contribute to increased intestinal permeability, facilitating the translocation of microbial products, and triggering the release of pro-inflammatory cytokines. This causes platelets to become hyperactive and secrete 5-HT into the plasma. Increased levels of pro-inflammatory cytokines may also lead to increased permeability of the blood-brain barrier (BBB), allowing inflammatory mediators entry into the brain, affecting the balance of TRP metabolism products, such as 5-HT, kynurenic acid (KYNA), and quinolinic acid (QUIN)." Rust goes on to say, "these alterations may contribute to neuroinflammation and possible neurological damage. Furthermore, platelets can cross the compromised BBB and interact with astrocytes and neurons, leading to the secretion of 5-HT and pro-inflammatory factors, exacerbating inflammatory conditions in the brain. "


Rust C, Malan-Muller S, van den Heuvel LL, Tonge D, Seedat S, Pretorius E, Hemmings SMJ. Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review. J Neuroimmunol. 2023 Jul 25;382:578155. doi: 10.1016/j.jneuroim.2023.578155. Epub ahead of print. PMID: 37523892.

The Legacy of Gulf War Syndrome: A Review of the Current Evidence




Gulf War Syndrome, also known as Gulf War illness, is a chronic and multisymptom condition that affects many veterans of the 1991 Persian Gulf War. Some of the common symptoms include fatigue, cognitive problems, musculoskeletal pain, skin rashes, and diarrhea [1]. However, the exact cause of this syndrome has been a matter of debate and controversy for decades.

One of the leading hypotheses is that exposure to sarin nerve gas, which was released when the U.S. and coalition forces bombed Iraqi chemical weapons facilities, was responsible for triggering Gulf War Syndrome in some veterans [2]. Sarin is a highly toxic substance that can cause convulsions, respiratory failure, and death. It can also damage the nervous system and affect brain function.

But not all veterans who were exposed to sarin developed Gulf War Syndrome. Why is that? A recent genetic study led by Dr. Robert Haley from UT Southwestern Medical Center may have found the answer. The study involved more than 1,000 Gulf War veterans, about half of whom had Gulf War Syndrome. The researchers also tested the veterans for two gene variants that affect how the body metabolizes sarin and some pesticides [3].

The results showed that veterans who had a weak variant of the gene that breaks down sarin were more likely to develop Gulf War Syndrome if they were exposed to sarin than those who had a strong variant of the gene. The weak variant was unable to clear sarin from the body quickly enough, leading to more damage to the nervous system. On the other hand, the strong variant was able to detoxify sarin more efficiently, reducing its harmful effects.

The study also found that another gene variant that processes some pesticides but not sarin had no effect on the risk of developing Gulf War Syndrome. This suggests that pesticides were not a major factor in causing the syndrome, contrary to some previous studies.

The findings of this study provide strong evidence that sarin nerve gas was the main cause of Gulf War Syndrome in many veterans. They also explain why some veterans were more vulnerable to the syndrome than others, depending on their genetic makeup. This could help improve the diagnosis and treatment of Gulf War Syndrome, as well as prevent similar illnesses in future conflicts.

Gulf War Syndrome is a serious and debilitating condition that affects many veterans who served their country with honor and courage. It is important to acknowledge their suffering and support their recovery. More research is needed to find better ways to help them cope with their symptoms and improve their quality of life.

Search this blog! #Gulf War Syndrome

Follow Environmental Illness Research News! Twitter/X   Join the Facebook Group   Facebook 



References:

[1] Gulf War Syndrome | Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/conditions-and-diseases/gulf-war-syndrome

[2] UTSW genetic study confirms sarin nerve gas as cause of Gulf War illness: Newsroom - UT Southwestern, Dallas, Texas. https://www.utsouthwestern.edu/newsroom/articles/year-2022/sarin-nerve-gas-gulf-war-illness.html

[3] Gulf War Illness symptoms baffled scientists. Until now. - DAV. https://www.dav.org/learn-more/news/2022/gulf-war-illness-has-baffled-scientists-until-now/

Microglia-mediated Neuroinflammation Is Implicated in Many Environmental Illnesses. What is it?




Neuroinflammation is a term that describes the activation of immune cells in the central nervous system (CNS) in response to various stimuli, such as infections, injuries, toxins, or neurodegenerative diseases [1]. Microglia are the resident immune cells of the CNS and are the main mediators of neuroinflammation. They act as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris, as well as producing inflammatory cytokines and chemokines that recruit other immune cells and modulate neuronal activity [2].

Microglia-mediated neuroinflammation can have both beneficial and detrimental effects on the CNS. On one hand, it can help to clear infections, repair tissue damage, and promote neurogenesis and synaptic plasticity [3]. On the other hand, it can also cause neuronal death, synaptic loss, oxidative stress, and blood-brain barrier disruption [4]. The balance between these effects depends on the type, intensity, duration, and location of the inflammatory stimulus, as well as the phenotype and function of microglia [5].

Microglia-mediated neuroinflammation has been implicated in various neurological disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. (See note.) In these disorders, microglia may become chronically activated and contribute to the pathological process by releasing pro-inflammatory mediators, enhancing oxidative stress, and promoting neurotoxicity [6]. Therefore, understanding the role of microglia in neuroinflammation and neurodegeneration may provide new insights into the pathogenesis and therapy of these diseases [7]. 


(Note - It has also been implicated in several 'environmental illnesses.)



Search the Blog! #microglia   #neuroinflammation

References:

[1] Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation. 2004;1:14.

[2] Muzio L, Viotti A, Martino G. Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy. Front Neurosci. 2021;15:742065.

[3] Ginhoux F, Lim S, Hoeffel G, Low D, Huber T. Origin and differentiation of microglia. Front Cell Neurosci. 2013;7:45.

[4] Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8(1):57-69.

[5] Ransohoff RM. A polarizing question: do M1 and M2 microglia exist? Nat Neurosci. 2016;19(8):987-991.

[6] Heneka MT, Carson MJ, El Khoury J et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14(4):388-405.

[7] Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol. 2014;10(4):217-224.

How Exercise Can Boost Your Brain Health and Prevent Alzheimer's Disease!





If you are looking for a natural and effective way to protect your brain from aging and cognitive decline, you might want to consider adding some physical activity to your daily routine. Exercise is not only good for your body, but also for your mind. In this blog post, we will explore how exercise can enhance your brain function, increase your memory, and reduce your risk of developing Alzheimer's disease.

## The Benefits of BDNF

One of the key mechanisms by which exercise benefits the brain is by increasing the production of a specialized protein called brain-derived neurotrophic factor (BDNF). BDNF is essential for brain formation, learning, memory, and neuroplasticity (the ability of the brain to form new connections and pathways). BDNF also promotes the survival of neurons and protects them from damage and degeneration.

Research has shown that BDNF levels are reduced in people with Alzheimer's disease, a neurodegenerative disorder that affects cognitive function, erodes memory, and alters personality. Alzheimer's disease is characterized by the accumulation of amyloid beta and phosphorylated tau proteins in the brain, which form plaques and tangles that impair neuronal communication and function. Alzheimer's disease also causes increased neuroinflammation and decreased nerve growth factor (NGF), another protein that supports neuronal health.

Exercise can counteract these negative effects by stimulating the release of BDNF in the brain. A recent study published in The Journal of Physiology showed that a short but intense bout of cycling increased BDNF levels by four to five-fold in healthy adults. The researchers suggested that this could extend the lifespan of a healthy brain and delay the onset of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

Another study published in Frontiers in Aging Neuroscience highlighted the therapeutic potential of exercise in preventing and treating Alzheimer's disease. The study indicated that moderate physical activity can help animals regain memory functions related to the hippocampus and amygdala, two primary brain regions affected by Alzheimer's disease. Exercise can also prevent the shrinkage of the hippocampus, which is essential for spatial memory.

## The Role of Irisin

Another way that exercise can protect the brain from Alzheimer's disease is by releasing a myokine called irisin. Irisin is a hormone that is produced by skeletal muscle during exercise and has various metabolic effects on the body. Irisin can also cross the blood-brain barrier and reach the brain, where it has neuroprotective properties.

According to a study published in Nature Medicine , irisin can prevent the accumulation of amyloid beta in the hippocampus by activating a cellular pathway that enhances its clearance. Amyloid beta is one of the main culprits behind Alzheimer's disease, as it forms toxic plaques that impair neuronal function and trigger inflammation. The study also showed that irisin can improve memory and synaptic plasticity in mice with Alzheimer's disease .

## How Much Exercise Do You Need?

The good news is that you don't need to spend hours at the gym to reap the benefits of exercise for your brain. According to the World Health Organization , adults aged 18-64 should do at least 150 minutes of moderate-intensity aerobic physical activity or 75 minutes of vigorous-intensity aerobic physical activity throughout the week. You can also do a combination of both. Moderate-intensity activities include brisk walking, cycling, or dancing. Vigorous-intensity activities include running, swimming, or playing sports .

Exercise can also be fun and enjoyable if you choose activities that suit your preferences, abilities, and goals. You can also exercise with friends or family to make it more social and motivating. The important thing is to be consistent and regular with your exercise routine, as this will ensure optimal results for your brain health.

## Conclusion

Exercise is a powerful tool that can boost your brain health and prevent Alzheimer's disease. By increasing BDNF, NGF, and irisin levels in your brain, exercise can enhance your cognitive function, memory, learning, and neuroplasticity. Exercise can also protect your neurons from damage and degeneration caused by amyloid beta, tau, and inflammation. To enjoy these benefits, you should aim to do at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week. Exercise can also improve your mood, energy, sleep quality, and overall well-being. So what are you waiting for? Start moving today and give your brain a boost!


: Gibbons T., et al., (2022). Six minutes of high-intensity exercise increases circulating BDNF concentrations in healthy adults: A randomized crossover trial. The Journal of Physiology.

: Alizadeh Pahlavani H., et al., (2021). The Effect of Exercise on BDNF and NGF in Alzheimer’s Disease: A Systematic Review and Meta-Analysis. Frontiers in Aging Neuroscience.

: Lourenco M.V., et al., (2019). Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine.

: World Health Organization. (2020). Physical activity. https://www.who.int/news-room/fact-sheets/detail/physical-activity

More Research is Needed on the Effects of Particulate Matter and Vascular Health!



"As wildfires continue to have devastating impacts in communities around the world and here in Canada, a team of researchers from York University say our current understanding of potential long-term health risks from particulate matter (PM) exposure are limited and mostly ignore the microvascular system." Read more...


The hazards of particulate matter

Particulate matter (PM) is a term that refers to tiny solid or liquid particles that are suspended in the air. PM can come from various sources, such as vehicle exhaust, industrial emissions, wildfires, dust storms, and volcanic eruptions. PM can have adverse effects on human health and the environment, depending on its size, composition, and concentration.

PM is classified into two main categories: PM10 and PM2.5. PM10 refers to particles that are 10 micrometers or less in diameter, while PM2.5 refers to particles that are 2.5 micrometers or less in diameter. PM2.5 is more dangerous than PM10 because it can penetrate deeper into the lungs and bloodstream, causing inflammation, oxidative stress, and cellular damage.

Some of the health effects of exposure to PM include respiratory problems, cardiovascular diseases, cancer, premature death, and reduced cognitive function. PM can also affect the climate by altering the radiation balance, cloud formation, and precipitation patterns. PM can also reduce visibility and damage crops, buildings, and monuments.

To reduce the hazards of PM, it is important to monitor its levels and sources, implement emission control measures, promote clean energy and transportation alternatives, and raise public awareness and education. Individuals can also protect themselves by avoiding outdoor activities when the air quality is poor, wearing masks or respirators, and using air purifiers or filters indoors.


TRPV and Fibromyalgia: What You Need to Know!


 

Fibromyalgia is a chronic condition that causes widespread pain, fatigue, and other symptoms. It affects about 2% of the population, mostly women, and can have a significant impact on quality of life. The exact cause of fibromyalgia is unknown, but it is thought to involve abnormal pain processing in the nervous system [1].

One of the possible factors involved in fibromyalgia pain is TRPV, or transient receptor potential vanilloid. TRPV is a family of ion channels that are expressed in sensory neurons and other tissues. They are activated by various stimuli, such as heat, acidity, and chemical compounds. Some of these compounds are found in spicy foods, such as capsaicin, the active ingredient in chili peppers [2].

TRPV channels play a role in pain perception and inflammation. They can modulate the activity of other pain receptors, such as opioid receptors, and influence the release of neurotransmitters, such as substance P and calcitonin gene-related peptide (CGRP). These neurotransmitters are involved in transmitting pain signals from the peripheral nerves to the spinal cord and brain [3].

Some studies have suggested that TRPV channels may be dysregulated in fibromyalgia patients. For example, one study found that fibromyalgia patients had higher levels of TRPV1 expression in their skin biopsies than healthy controls [4]. Another study found that fibromyalgia patients had lower levels of TRPV4 expression in their blood cells than healthy controls [5].

The implications of these findings are not clear yet, but they may indicate that TRPV channels are involved in the pathophysiology of fibromyalgia. They may also offer potential targets for new treatments. For example, some drugs that block or activate TRPV channels have been shown to have analgesic effects in animal models and human trials. These drugs include capsaicin creams, resiniferatoxin injections, and olvanil capsules [6].

However, more research is needed to confirm the role of TRPV channels in fibromyalgia and to evaluate the safety and efficacy of TRPV modulators for fibromyalgia patients. Until then, patients should consult their doctors before trying any new treatments or supplements that may affect TRPV channels.

Search the Blog! #fibromyalgia

References:

[1] Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55.

[2] Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23;389(6653):816-24.

[3] Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov. 2007 May;6(5):357-72.

[4] Kim SH, Kim DH, Oh DH et al. Increased expression of N-methyl-D-aspartate receptor subunit 2D in the skin of patients with fibromyalgia. Rheumatology (Oxford). 2015 Jun;54(6):1068-76.

[5] Kim DH, Kim SH et al. Decreased expression of transient receptor potential vanilloid 4 in the dorsal root ganglion and skin biopsies from patients with fibromyalgia syndrome. Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 116(5):S27-S33.

[6] Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth. 2011 Oct;107(4):490-502.

Understanding Multiple Chemical Sensitivity!





Multiple Chemical Sensitivity (MCS) is a condition that affects some people who are exposed to various chemicals in the environment. MCS is not a specific diagnosis, but rather a term that describes a range of symptoms that can be triggered by low levels of chemical exposure. Some of the common symptoms of MCS include headaches, fatigue, nausea, skin rashes, asthma, and cognitive impairment [1]. MCS can affect different people in different ways, and the severity of the symptoms can vary depending on the type and amount of chemical exposure.

MCS is not well understood by the medical community, and there is no consensus on its causes, diagnosis, or treatment. Some researchers believe that MCS is a form of environmental illness, where the body's immune system becomes hypersensitive to certain chemicals and reacts with inflammation and oxidative stress [2]. Other researchers suggest that MCS is a psychological phenomenon, where the person develops a conditioned response to certain stimuli and experiences anxiety and somatic symptoms [3]. There is also a debate on whether MCS is a distinct disorder or a symptom of another underlying condition, such as chronic fatigue syndrome, fibromyalgia, or depression [4].

The lack of scientific agreement on MCS makes it challenging for people who suffer from it to find adequate medical care and social support. Many doctors are unfamiliar with MCS or dismiss it as a psychosomatic disorder [5]. Many people with MCS face stigma and isolation from their family, friends, and coworkers who do not understand their condition or doubt its validity [6]. Many people with MCS also struggle with finding safe and accessible housing, workplaces, and public spaces that are free of chemical triggers [7].

If you have MCS or suspect that you might have it, it is important to seek professional help from a doctor who is knowledgeable and supportive of your condition. You may also benefit from joining a support group or an advocacy organization for people with MCS, where you can share your experiences and learn from others who face similar challenges [8]. You may also want to consult with an environmental specialist who can help you identify and reduce your exposure to potential chemical triggers in your home and workplace [9]. Finally, you may want to explore various coping strategies that can help you manage your symptoms and improve your quality of life, such as relaxation techniques, cognitive-behavioral therapy, or alternative therapies [10].

Search this blog: #MCS

References:

[1] Gibson PR. Multiple chemical sensitivity: A survival guide. New Harbinger Publications; 2006.

[2] Pall ML. Multiple chemical sensitivity: toxicological questions and mechanisms. General Hospital Psychiatry. 2002 Jul 1;24(4):216-20.

[3] Barsky AJ, Borus JF. Functional somatic syndromes. Annals of internal medicine. 1999 Jun 1;130(11):910-21.

[4] Jason LA, Taylor RR, Kennedy CL. Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms. Psychosomatic medicine. 2000 Sep 1;62(5):655-63.

[5] Kipen HM, Fiedler N. Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge. Environmental health perspectives. 2002 Jun;110(suppl 4):597-9.

[6] Gibson PR, Lindberg A. Physicians' perceptions and practices regarding patient reports of multiple chemical sensitivity. ISRN nursing. 2011 Dec 22;2011.

[7] Gibson PR. Of the world but not in it: barriers to community access and education for persons with environmental sensitivities. Health care for women international. 2009 Jan 1;30(1-2):34-47.

[8] Gibson PR, Sledd LG. Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity. Environmental health perspectives. 2007 Sep;115(9):1328-33.

[9] Rea WJ. Chemical sensitivity: tools of diagnosis and methods of treatment: Vol I-IV CRC Press; 1997.

[10] Gibson PR. Multiple chemical sensitivity: coping mechanisms. CRC Press; 2000.

MCS is Caused from Mast Cell Activation, New Study Says!

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What is loss of tolerance and why does it happen?

Loss of tolerance is a condition where the body becomes hypersensitive to substances or stimuli that were previously tolerated. This can result in allergic reactions, inflammation, chronic pain, fatigue, and other symptoms. Loss of tolerance can affect various systems in the body, such as the immune system, the nervous system, the endocrine system, and the digestive system.

There are different theories about why loss of tolerance occurs, but some possible factors are:

- Genetic predisposition

- Environmental exposure to toxins, pollutants, or infections

- Stress, trauma, or emotional distress

- Hormonal changes or imbalances

- Nutritional deficiencies or imbalances

- Gut dysbiosis or leaky gut syndrome

- Autoimmune disorders or chronic inflammation


Loss of tolerance can be difficult to diagnose and treat, as the triggers and symptoms may vary from person to person. However, some general strategies that may help are:

- Identifying and avoiding the substances or stimuli that cause reactions

- Supporting the body's detoxification and elimination processes

- Reducing stress and enhancing relaxation

- Balancing the hormones and restoring the circadian rhythm

- Improving the gut health and microbiome diversity

- Modulating the immune system and reducing inflammation

- Seeking professional guidance from a qualified health practitioner


(Beyond Pesticides, August 22, 2023) A recently completed study (available in preprint before peer review) identifies the development of what the authors term “Toxicant-Induced Loss of Tolerance” (TILT), the constellation of symptoms associated with chemical exposures. The authors describe a two-part process. Read more...

The Best Way to get More NRF2 in Your Diet!





NRF2 activators are substances that can boost the activity of a protein called NRF2, which is responsible for turning on hundreds of genes that protect our cells from oxidative stress, inflammation, and toxins. NRF2 activators can be found in many natural foods, supplements, and medications, and they have been shown to have various health benefits, such as preventing or treating some diseases.

Some of the most common and potent NRF2 activators are:

- Sulforaphane: This is a compound found in cruciferous vegetables like broccoli, kale, cabbage, and cauliflower. It can activate NRF2 by modifying a protein called KEAP1, which normally inhibits NRF2. Sulforaphane has been studied for its anti-cancer, anti-inflammatory, and neuroprotective effects. 

- Curcumin: This is the main active ingredient in turmeric, a spice widely used in Asian cuisine. It can activate NRF2 by modulating various signaling pathways, such as MAPK, PI3K/Akt, and NF-kB. Curcumin has been studied for its anti-cancer, anti-inflammatory, and antioxidant effects. 

- Resveratrol: This is a polyphenol found in grapes, red wine, berries, and peanuts. It can activate NRF2 by interacting with a molecule called SIRT1, which regulates gene expression and cellular aging. Resveratrol has been studied for its anti-aging, anti-diabetic, and cardioprotective effects. 

- Green tea catechins: These are antioxidants found in green tea, such as epigallocatechin gallate (EGCG). They can activate NRF2 by inhibiting an enzyme called NQO1, which regulates the degradation of NRF2. Green tea catechins have been studied for their anti-cancer, anti-obesity, and anti-inflammatory effects. 

- Omega-3 fatty acids: These are essential fats found in fish oil, flaxseed oil, walnuts, and chia seeds. They can activate NRF2 by binding to a receptor called PPAR-gamma, which regulates gene expression and metabolism. Omega-3 fatty acids have been studied for their anti-inflammatory, anti-depressive, and neuroprotective effects. 

There are many other NRF2 activators that have been identified or are being investigated, such as garlic, ginger, cinnamon, cocoa, coffee, blueberries, pomegranate, rosemary, and more. The best way to get the benefits of NRF2 activation is to eat a varied and balanced diet that includes plenty of fruits, vegetables, herbs, spices, nuts, seeds, and other whole foods that contain these natural compounds.

I hope this helps you understand what NRF2 activators are and why you should be eating them. If you want to learn more about them or how they work in your body, you can check out these sources:


: https://biosignaling.biomedcentral.com/articles/10.1186/s12964-022-00906-3

: https://beyondmicrogreens.com/blogs/microgreens-news/nrf2-activators-sulforaphane


Probiotics can Reduce Brain Neurotoxicity from Mold, Study Suggests!!


Probiotics can Reduce Brain Neurotoxicity from Mold, Study Suggests!!

Aytekin writes. "The most harmful and prevalent type of AF in food and feed is AFB1. AFB1 exposure is hazardous to many organs, but brain studies are scarce. To our knowledge, "no study has examined probiotics and AFB1-induced neurotoxicity. Thus, we investigated if probiotics could reduce brain neurotoxicity caused by AFB1."

Probiotics may reduce AFB1's neurotoxicity. Our investigation found "that antioxidant and anti-inflammatory activities of Bifidobacterium and Lactobacillus species can reduce AFB1-induced neurotoxicity."

Aytekin Sahin G, Karabulut D, Unal G, Sayan M, Sahin H. Effects of probiotic supplementation on very low dose AFB1-induced neurotoxicity in adult male rats. Life Sci. 2022 Oct 1;306:120798. doi: 10.1016/j.lfs.2022.120798. Epub 2022 Jul 14. PMID: 35843344. Effects of probiotic supplementation on very low dose AFB1-induced neurotoxicity in adult male rats - ScienceDirect


Search this blog: #mold   #probiotics



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Thursday, August 24, 2023

The Relationship Between Parkinson's, Gut Health and Neuroinflammation



 

Axial Biotherapeutics stated that Caltech researchers led by scientific founder Sarkis K. Mazmanian, Ph.D., have established a novel molecular relationship between the gut microbiome and Parkinson's disease. Gut bacteria promoted nervous system inflammation and motor impairment in a validated PD mouse model. The findings show that addressing the gut microbiome may help diagnose and treat Parkinson's disease. The online Cell article, “Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease,” now available.

Over the past few years, evidence has grown that the gut microbiome is crucial to human health and disease. Bidirectional gut-brain connection is also linked to neurological illnesses such anxiety, depression, and autism spectrum disorders. The Cell study is the first to suggest that gut bacteria may be linked to Parkinson's disease. This discovery may help identify gut microorganisms that affect PD. These bacteria may be employed as biomarkers, PD risk factors, novel therapeutic targets, or microbial-based therapeutics in the future.
“Our findings offer a new perspective on how environmental factors may cause Parkinson's disease and other neurodegenerative diseases. The idea that gut pathology may affect these diseases is a radical departure from conventional neuroscience research, said Dr. Sarkis Mazmanian, the Louis & Nelly Soux Professor of Microbiology in the Division of Biology and Biological Engineering at the California Institute of Technology and Scientific Founder of Axial Biotherapeutics. Parkinson's disease is complex and has several genetic predispositions and environmental dangers, but we believe our findings illuminate a previously unknown and possibly essential aspect of this puzzle.”
Dr. Mazmanian added, “Gut bacteria in Parkinson's patients are different from healthy individuals. When we transplanted Parkinson's microbiomes into mice, motor impairments and neuroinflammation were worse than in mice with healthy gut bacteria. This shows a fundamental link between gut microbes and Parkinson's disease processes.”
A mouse model of Parkinson's disease that overexpresses alpha-synuclein was used for the tests. PD is hypothesized to be caused by this protein. The mice were raised in a germ-free environment. The researchers could then study how gut bacteria affected mouse disease outcomes using germ-free animals. Fecal microbiota transplants from PD patients increased motor deficits, inflammation, and alpha-synuclein aggregation in the model system compared to healthy donor transplants.
Researchers also found microbial metabolites that cause PD in mice. These data imply gut bacteria may cause PD in genetically prone people. Caltech, UC San Diego, Arizona State University, Chalmers University of Technology, Gothenburg, UC Los Angeles, Rush University Medical Center, Chicago, and UW-Madison collaborated on the study.
Dr. Mazmanian said, “Gut bacteria provide immense physiological benefit, and we do not yet have the data to know which species are problematic or beneficial in Parkinson’s disease. It is critical to emphasize that no human antibiotic or microbial therapy can match the effect we found in mice. We will next investigate gut bacteria that may contribute to Parkinson's disease to develop novel biomarkers to identify at-risk patients. These findings could also lead to safer, more effective therapeutic techniques that circumvent brain drug delivery issues.
T. Sampson, J. Debelius, T. Thron, S. Janssen, G. Shastri, Z. Ilhan, Z., S. Mazmanian (2016). Cell, 167(6). Gut microbiota regulate motor deficits and neuroinflammation in a Parkinson's disease model. doi:10.1016/j.cell.2016.11.018

What to Know About NRF2 and Probiotics




 Hi everyone, welcome back to my blog! Today I want to talk to you about two things that are very important for your health: probiotics and Nrf2. You may have heard of probiotics before, but what are they exactly? Probiotics are live microorganisms that can benefit your gut health and immune system. They can be found in foods like yogurt, kefir, sauerkraut, kimchi, and kombucha. Probiotics can help balance your gut flora, prevent infections, improve digestion, and reduce inflammation.

But what is Nrf2 and how does it relate to probiotics? Nrf2 is a protein that regulates the expression of antioxidant genes in your cells. Antioxidants are molecules that protect your cells from oxidative stress, which is caused by free radicals. Free radicals are unstable atoms that can damage your DNA, proteins, and membranes. Oxidative stress can lead to aging, inflammation, and chronic diseases like cancer, diabetes, and Alzheimer's.

Nrf2 is activated by various stimuli, such as exercise, fasting, and phytochemicals. Phytochemicals are plant compounds that have beneficial effects on your health. Some examples of phytochemicals are curcumin, resveratrol, sulforaphane, and quercetin. These compounds can modulate Nrf2 activity and increase your antioxidant defense.

But how do probiotics fit into this picture? Well, some studies have shown that probiotics can also influence Nrf2 expression and function. For instance, a study by Wang et al. (2017) found that a probiotic strain called Lactobacillus plantarum CCFM639 could enhance Nrf2 activation and reduce oxidative stress in mice with liver injury. Another study by Zhang et al. (2018) showed that a probiotic mixture containing Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 could increase Nrf2 levels and antioxidant enzymes in elderly subjects.

These findings suggest that probiotics may have a synergistic effect with phytochemicals in boosting your Nrf2 pathway and protecting your cells from oxidative damage. Therefore, consuming probiotics and phytochemicals together may be a good strategy to improve your health and prevent disease.

I hope you enjoyed this blog post and learned something new. If you have any questions or comments, please leave them below. And don't forget to subscribe to my blog for more updates on health and wellness. Thanks for reading!

Read more; #Probiotics

: Wang Y., Wu Y., Wang Y., Xu H., Mei X., Yu D., Wang Y., Li W. (2017). Antioxidative effects of Lactobacillus plantarum via activation of the Nrf2 pathway. Food Funct., 8(3), 1174-1183.

: Zhang J., Wang L., Liu Y., Zhao F., Wei H., Yan F., Sun J., Xu H., Qiao J., Chen W. (2018). Effects of a mixture of Lactobacillus and Bifidobacterium on the gut microbiota and metabolic profiles in aging mice. Food Funct., 9(12), 6114-6124.

Learn More About the Mediterranean Diet! It is Good for Environmental Illness

 



A Mediterranean diet is a way of eating that emphasizes fruits, vegetables, legumes, and whole grains. It includes fewer ultra-processed foods and less meat than a typical Western diet. Read more...

If you are looking for a simple and healthy way to eat, you might want to try the Mediterranean Diet. This is a dietary pattern that is based on the traditional foods and drinks of the countries that border the Mediterranean Sea, such as Greece, Italy, Spain, and Morocco. The Mediterranean Diet is rich in fruits, vegetables, whole grains, beans, nuts, seeds, olive oil, fish, and moderate amounts of dairy, eggs, poultry, and wine. It is low in red meat, processed foods, added sugars, and saturated fats.

Here is a generic 7-day menu for the Mediterranean Diet that you can use as a guide. You can adjust the portions and ingredients according to your preferences and needs.

Day 1
Breakfast: Greek yogurt with fresh berries and granola
Lunch: Lentil soup with whole wheat bread and salad
Dinner: Baked salmon with roasted vegetables and quinoa
Snack: Hummus with carrot sticks

Day 2
Breakfast: Oatmeal with sliced almonds and honey
Lunch: Chicken and vegetable wrap with tzatziki sauce
Dinner: Spaghetti with tomato sauce and cheese
Snack: Fresh fruit salad

Day 3
Breakfast: Scrambled eggs with spinach and feta cheese
Lunch: Tomato and cucumber salad with pita bread and olives
Dinner: Lamb chops with couscous and mint yogurt
Snack: Dates stuffed with walnuts

Day 4
Breakfast: Whole wheat pancakes with maple syrup and berries
Lunch: Vegetable and bean stew with brown rice
Dinner: Roasted chicken with potatoes and green beans
Snack: Cheese and crackers

Day 5
Breakfast: Smoothie made with banana, milk, oats, and peanut butter
Lunch: Tuna salad sandwich with lettuce and tomato
Dinner: Vegetable paella with shrimp and mussels
Snack: Dried figs and almonds

Day 6
Breakfast: French toast with fresh fruit and whipped cream
Lunch: Roasted vegetable and feta cheese pizza
Dinner: Grilled steak with roasted asparagus and baked potato
Snack: Dark chocolate and red wine

Day 7
Breakfast: Omelet with mushrooms, cheese, and herbs
Lunch: Minestrone soup with parmesan cheese and breadsticks
Dinner: Greek salad with grilled chicken and pita bread
Snack: Baklava and tea