# **NIH Study Offers New Clues into the Causes of Post-Infectious ME/CFS**
In a groundbreaking clinical study, researchers at the National Institutes of Health (NIH) have made significant strides in understanding the underlying mechanisms of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS). This debilitating condition affects millions of people worldwide, causing severe fatigue, cognitive impairment, and other distressing symptoms. Despite its prevalence, uncovering the biological basis of ME/CFS has been an ongoing challenge.
The NIH study delved into both the brains and immune systems of individuals with PI-ME/CFS. Here are some key findings:
1. **Brain Activity**: Using functional magnetic resonance imaging (fMRI), researchers discovered that people with ME/CFS exhibit lower activity in a brain region called the temporal-parietal junction (TPJ). This reduced activity may contribute to feelings of fatigue by disrupting how the brain decides how to exert effort.
2. **Catecholamine Levels**: Analysis of spinal fluid revealed abnormally low levels of catecholamines and other molecules that regulate the nervous system in ME/CFS patients compared to healthy controls. Reduced catecholamine levels were associated with worse motor performance, effort-related behaviors, and cognitive symptoms.
3. **Immune System Markers**: Immune testing showed that individuals with ME/CFS had higher levels of naive B cells and lower levels of switched memory B cells in their blood. Naive B cells respond to any given antigen encountered, while memory B cells specifically target particular antigens. These immune markers may play a role in brain dysfunction and fatigue.
## **Gender Differences**
Interestingly, the study also revealed distinct differences between men and women with PI-ME/CFS. These gender-specific variations warrant further investigation to better understand the disease's nuances.
## **Implications for Treatment**
Dr. Avindra Nath, clinical director at NIH's National Institute of Neurological Disorders and Stroke (NINDS) and senior author of the study, emphasized that these findings provide critical insights into ME/CFS. Researchers can now explore whether these factors apply to a larger patient group and develop better treatments for patients.
No comments:
Post a Comment